Applegate guest-starred in 21 Jump Street (1988) and Top of the Heap (1991, as Kelly Bundy), and hosted Saturday Night Live (May 8, 1993, and October 13, 2012) and MADtv (1996).The character of Sue Ellen Crandell in the black comedy feature Don't Tell Mom the Babysitter's Dead (1991) was Applegate's first starring role in a mainstream film, playing a rebellious teenager who is forced to take care of siblings after their summer babysitter dies. with Children was cancelled in May 1997, Applegate starred as Claudine Van Doozen in the independent feature Claudine's Return (or Kiss of Fire), was cast in the action-comedy The Big Hit, and played the fiancée of a mob descendant in the Mafia satire Jane Austen's Mafia (1998).
In 2004, she debuted on the Broadway stage playing the title role of Charity Hope Valentine in a revival of the 1966 musical Sweet Charity.
In late April 2005, she also took part in the annual Broadway Cares’ Easter Bonnet Competition, being sawed in half by a magician in their Clearly Impossible sawing illusion.
Applegate was previously married to Johnathon Schaech for six years.
who as an adolescent actress started playing the role of Kelly Bundy on the Fox sitcom Married... In her adult years, Applegate established a film and television career, winning an Emmy and earning Tony and Golden Globe nominations.
Applegate followed with roles in films such as Vibrations (1995), Across the Moon (1995), Wild Bill (1995), Tim Burton's Mars Attacks! Applegate was one of the founding members of The Pussycat Dolls, which debuted at Johnny Depp's Viper Room on the Sunset Strip in 1995.